DeubiKuitylation: A novel DUB enzymatic activity for the DNA repair protein, Ku70
نویسندگان
چکیده
منابع مشابه
Mutant huntingtin impairs Ku70-mediated DNA repair
DNA repair defends against naturally occurring or disease-associated DNA damage during the long lifespan of neurons and is implicated in polyglutamine disease pathology. In this study, we report that mutant huntingtin (Htt) expression in neurons causes double-strand breaks (DSBs) of genomic DNA, and Htt further promotes DSBs by impairing DNA repair. We identify Ku70, a component of the DNA dama...
متن کاملMismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair
MSH6, a key component of the MSH2-MSH6 complex, plays a fundamental role in the repair of mismatched DNA bases. Herein, we report that MSH6 is a novel Ku70-interacting protein identified by yeast two-hybrid screening. Ku70 and Ku86 are two key regulatory subunits of the DNA-dependent protein kinase, which plays an essential role in repair of DNA double-strand breaks (DSBs) through the non-homol...
متن کاملProtein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86.
DNA ends are generated during double-strand-break repair and recombination. A p70-p86 heterodimer, Ku, accounts for the DNA end binding activity in eukaryotic cell extracts. When one or both subunits of Ku are missing, mammalian cells are deficient in double-strand-break repair and in specialized recombination, such as V(D)J recombination. Little is known of which regions of Ku70 and Ku86 bind ...
متن کاملEnzymatic Repair of Oxidative DNA Damage1
Oxidative DNA damage, including both mutamente and cytotoxic le sions, is implicated in aging and cancer. Studies of the processes which correct such damage in mammalian cells are, however, still in their early stages. Here we have summarized our recent work which demonstrates new features of mammalian oxidative UNA damage repair, such as (a) a functional role for polylADP-ribosyllation in the ...
متن کاملKu70, a Component of DNA-Dependent Protein Kinase, Is a Mammalian Receptor for Rickettsia conorii
Rickettsia conorii, a strictly intracellular and category C priority bacterial pathogen (NIAID), invades different mammalian cells. Although some signaling events involved in bacterial entry have been documented, the bacterial and host proteins mediating entry were not known. We report the identification of the Ku70 subunit of DNA-dependent protein kinase (DNA-PK) as a receptor involved in R. c...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2009
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.8.12.8864